An exploratory clinical study of p38α kinase inhibition in Alzheimer's disease.
Philip ScheltensNiels PrinsAdriaan LammertsmaMaqsood YaqubAlida GouwAlle Meije WinkHui-May ChuBart N M van BerckelJohn AlamPublished in: Annals of clinical and translational neurology (2018)
Selective p38α inhibition in patients with early AD may improve episodic memory and potentially impact β-amyloid production. These preliminary clinical findings support conduct of a longer duration placebo-controlled study, particularly to confirm the effects on episodic memory function.