Monitoring tumour microenvironment changes during anti-angiogenesis therapy using functional MRI.
Jianye LiangQingqing ChengJiaxi HuangMengjie MaDong ZhangXueping LeiZeyu XiaoDongmei ZhangChangzheng ShiLiang-Ping LuoPublished in: Angiogenesis (2019)
Intermittent application of low-dose anti-angiogenic inhibitor treatment may help improve the effect of chemotherapy by reducing hypoxia-related treatment resistance and improving drug delivery. DCE-MRI is useful for evaluating vessel maturity and vascular normalization, while BOLD-MRI may help to predict tumour hypoxia and metastatic potential after anti-vascular treatment.
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