Platelet phagocytosis via PSGL1 and accumulation of microparticles in systemic sclerosis.

Angelo A ManfrediGiuseppe Alvise RamirezCosmo GodinoAnnalisa CapobiancoAntonella MonnoStefano FranchiniEnrico TombettiSara CorradettiJörg Hw DistlerMarco E BianchiPatrizia Rovere-QueriniNorma Maugeri

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2021)

The clearance of activated platelets via PSGL-1 limits undesirable effects of µPs-elicited neutrophil activation. This balance is disrupted in patients with SSc. Its reconstitution might curb vascular inflammation and prevent fibrosis.

Keyphrases

systemic sclerosis
interstitial lung disease
oxidative stress
resting state
rheumatoid arthritis
red blood cell