Microrod crystals formed via Rhein-mediated mineralization.

Jiaying LiuZhenyan ZhangYu YanXiaonong ZhangChunsheng Xiao Xuesi Chen

Published in: Chemical communications (Cambridge, England) (2023)

Herein, a Rhein-mineralized microrod crystal (H-RMM) with an ultra-high drug loading capacity was reported for anti-inflammation. Due to a dense crystal structure, the H-RMM achieved improved biocompatibility and sustained controlled release of Rhein. Also, the Rhein nanofibers released from H-RMM were favorable to be internalized by cells, leading to enhanced anti-inflammation effects.

Keyphrases

crystal structure
oxidative stress
induced apoptosis
cell cycle arrest
high resolution
emergency department
signaling pathway
mass spectrometry