Synthesis of Six-Membered N -Heterocyclic Carbene Precursors Based on Camphor.

Jan ŠeginaLuka CiberHelena BrodnikFranc Požgan Jurij Svete Bogdan Štefane Uroš Grošelj

Published in: Molecules (Basel, Switzerland) (2023)

The endo - and exo - N -heterocyclic carbene precursors based on camphor were prepared diastereoselectively in five synthetic steps starting from (1 S )-(+)-ketopinic acid. The obtained N -heterocyclic carbene precursors were investigated in an asymmetric benzoin reaction. All new compounds were fully characterized, and the absolute configurations were determined via X-ray diffraction and NOESY measurements.

Keyphrases

high resolution
electron microscopy
computed tomography
dual energy
mass spectrometry
crystal structure
single molecule