Scrodentoids H and I, a Pair of Natural Epimerides from Scrophularia dentata, Inhibit Inflammation through JNK-STAT3 Axis in THP-1 Cells.

Gaohui MaoLiqin SunJin-Wen XuYiming LiCiren DunzhuLiuqiang Zhang Fei Qian

Published in: Evidence-based complementary and alternative medicine : eCAM (2020)

Our experimental results indicated that anti-inflammatory effects of SHI exhibit attenuation of LPS-induced inflammation and inhibit activation through JNK/STAT3 pathway in macrophages. These results suggest that SHI might have a potential in treating inflammatory disease.

Keyphrases

induced apoptosis
oxidative stress
lps induced
inflammatory response
anti inflammatory
signaling pathway
endoplasmic reticulum stress
cell death
cell proliferation
cell cycle arrest
climate change