Merlin immunohistochemistry is useful in diagnosis of tumours within the spectrum of biphasic hyalinizing psammomatous renal cell carcinoma.

Katrina M CollinsMichael HwangTatjana AnticAjit PaintalPedram ArganiAndres MatosoArun GopinathBrett BaskovichRohit Mehra Sean R Williamson Muhammad T IdreesJustine A BarlettaWilliam J AndersonMichelle S HirschJason L Hornick Andres Martin Acosta

Published in: Histopathology (2022)

In this study, merlin IHC was ~92% sensitive and ~94% specific for BHP RCC. These data suggest that merlin IHC is a reliable surrogate marker for the presence of underlying NF2 gene inactivation, being diagnostically useful to identify BHP RCC.

Keyphrases

renal cell carcinoma
signaling pathway
oxidative stress
lps induced
electronic health record
copy number
nuclear factor
gene expression
pi k akt
immune response
dna methylation
toll like receptor
genome wide identification
data analysis
transcription factor