Defective fibrin deposition and thrombus stability in Bambi-/- mice are mediated by elevated anticoagulant function.

James T B CrawleyArgita ZalliJames H MonkmanAnastasis PetriDavid A Lane Herm Jan M Brinkman Isabelle I Salles-Crawley

Published in: Journal of thrombosis and haemostasis : JTH (2019)

We demonstrate that endothelial BAMBI influences fibrin generation and thrombus stability by modulating thrombomodulin and TFPI anticoagulant function of the endothelium; we also highlight the importance of these anticoagulant proteins in the laser-induced thrombosis model.

Keyphrases

atrial fibrillation
venous thromboembolism
nitric oxide
pulmonary embolism
endothelial cells
signaling pathway
platelet rich plasma
high fat diet induced
type diabetes
metabolic syndrome
insulin resistance