Swimming training prevents obesity installation and normalizes hypothalamic expressions of GLP1 and leptin receptors in adult offspring born in small litters.
Stefani Valeria FischerBruna Schumaker SiqueiraClaudia Regina Capriglioni CancianElisangela Gueiber MontesViviane Nogaroto VicariPaulo Vinicius SvidnickiSabrina GrassiolliPublished in: Einstein (Sao Paulo, Brazil) (2024)
Lactational hypernutrition induces obesity and metabolic dysfunction in adult life, in association with higher hypothalamic expressions of the Lep-R and GLP1-R genes. Exercise prevented obesity and improved metabolic state in SL overnourished rats, and normalized their hypothalamic Lep-R and GLP1-R gene expressions.
Keyphrases
- insulin resistance
- metabolic syndrome
- weight loss
- high fat diet induced
- type diabetes
- weight gain
- genome wide
- high fat diet
- physical activity
- adipose tissue
- oxidative stress
- genome wide identification
- skeletal muscle
- gene expression
- body mass index
- copy number
- dna methylation
- gestational age
- virtual reality
- resistance training