Comprehensive genomic profiling of Brazilian non-small cell lung cancer patients (GBOT 0118/LACOG0418).

Eldsamira MascarenhasAna Caroline GelattiLuiz Henrique AraújoClarissa BaldottoClarissa MathiasMauro ZukinGustavo WerutskyPatricia PachecoRafaela GomesGilberto de CastroVladmir Cláudio Cordeiro de Lima

Published in: Thoracic cancer (2020)

TP53 was the most commonly comutated gene across samples. TP53 p.R337H was associated with somatic mutations in EGFR and ERBB2. Most samples had low TMB; only 5.5% of samples had high TMB.

Keyphrases

copy number
end stage renal disease
small cell lung cancer
tyrosine kinase
newly diagnosed
ejection fraction
chronic kidney disease
epidermal growth factor receptor
genome wide
single cell
gene expression
dna methylation
genome wide analysis