Decreased VMAT2 in the pancreas of humans with type 2 diabetes mellitus measured in vivo by PET imaging.
Mariette T AckermansMika NaganawaLaigao ChenKristin ChidseySantos Carvajal-GonzalezSylvester PawlakMichelle RossulekYanwei ZhangJason BiniTimothy J McCarthyRichard E CarsonRoberto A CallePublished in: Diabetologia (2018)
The observed correlations of VMAT2 density in the pancreas and pancreas regions with years since diagnosis of type 2 diabetes, glycaemic control and beta cell function suggest that loss of BCM contributes to deficient insulin secretion in humans with type 2 diabetes.