Erythroid Differentiation of Induced Pluripotent Stem Cells Co-cultured with OP9 Cells for Diagnostic Purposes.

Juhye Roh Shinyoung Kim June-Won Cheong Su-Hee Jeon Hyun-Kyung Kim Moon-Jung Kim Hyun Ok Kim

Published in: Annals of laboratory medicine (2022)

We generated blood group antigen-expressing nucleated RBCs from iPSCs co-cultured with OP9 cells that can be used for diagnostic purposes. iPSCs from rare blood group donors could serve as an unlimited source for reagent production.

Keyphrases

induced pluripotent stem cells
induced apoptosis
cell cycle arrest
endoplasmic reticulum stress
signaling pathway
cell death
oxidative stress