Invasive growth of brain metastases is linked to CHI3L1 release from pSTAT3-positive astrocytes.

Matthew DanknerSarah M MaritanNeibla PriegoGeorgia KruckAndriniaina Nkili-MeyongJavad NadafRebecca ZhuangMatthew G AnnisDongmei ZuoAlexander NowakowskiMarco BiondiniAlexander KiepasCaitlyn MourcosPhuong LeFrancois CharronYanis InglebertPaul SavageLouis ThéretMarie-Christine GuiotR Anne McKinneyWilliam J MullerMorag ParkManuel ValienteKevin PetreccaPeter M Siegel

Published in: Neuro-oncology (2024)

Together, these data reveal that pSTAT3+ RA-derived CHI3L1 is associated with BrM invasion, implicating STAT3 and CHI3L1 as clinically relevant therapeutic targets for the treatment of HI BrM.

Keyphrases

brain metastases
small cell lung cancer
rheumatoid arthritis
cell proliferation
big data
genome wide
single cell
gene expression
data analysis