Endothelial deficiency of insulin-like growth factor-1 receptor leads to blood-brain barrier disruption and accelerated endothelial senescence in mice, mimicking aspects of the brain aging phenotype.
Rafał GulejBoglarka CsikJanet FaakyeStefano TarantiniSantny ShanmugaramaChandragiri Siva SaiPeter MukliShannon M ConleyAnna CsiszarZoltan UngvariAndriy YabluchanskiyÁdám Nyúl-TóthPublished in: Microcirculation (New York, N.Y. : 1994) (2023)
These findings support the notion that IGF-1 signaling plays a crucial role in preserving a youthful cerebromicrovascular endothelial phenotype and maintaining the integrity of the BBB.