Neutrophil extracellular trap stabilization by platelet factor 4 reduces thrombogenicity and endothelial cell injury.
Anh T P NgoAmrita SarkarIrene YarovoiNate D LevineVeronica BochenekGuohua ZhaoLubica RauovaM Anna KowalskaKaitlyn EckartNilam S MangalmurtiAnn RuxDouglas B CinesMortimer PonczKandace GollompPublished in: bioRxiv : the preprint server for biology (2023)
In contrast to intact NETs, degraded NETs and cfDNA are prothrombotic and injure the endothelium.PF4 reduces the ability of degraded NETs and cfDNA to promote thrombosis and injure the endothelium.