Growth Differentiation Factor 7 Prevents Sepsis-Induced Acute Lung Injury in Mice.
Ping DongYing ZhangNian LiuJun-Yuan YangHui-Min WangQing GengPublished in: Evidence-based complementary and alternative medicine : eCAM (2022)
GDF7 prevents LPS-induced inflammatory response, oxidative stress, and ALI by regulating the STING/AMPK pathway. Our findings for the first time identify GDF7 as a potential agent for the treatment of sepsis-induced ALI.
Keyphrases
- lps induced
- inflammatory response
- diabetic rats
- lipopolysaccharide induced
- oxidative stress
- high glucose
- acute kidney injury
- intensive care unit
- toll like receptor
- septic shock
- drug induced
- skeletal muscle
- endothelial cells
- dna damage
- combination therapy
- risk assessment
- adipose tissue
- climate change
- induced apoptosis