Regulation of autophagy by circular RNAs in rheumatoid arthritis: Potential targets of action.
Yuedi HuJian LiuHui JiangLei WanYajun QiQiao ZhouYanyan FangYanqiu SunPublished in: International journal of rheumatic diseases (2023)
Previous studies have shown that autophagic pathogenesis of rheumatoid arthritis (RA) is regulated by circular RNAs (circRNAs), which accelerate bone damage by participating in the immune inflammatory response. Therefore, exploring the mechanisms underlying circRNA regulation of autophagy is essential for maintaining homeostasis of the skeletal microenvironment in RA and may improve our understanding of the specific pathways involved in the development of therapeutics. In this review, we discuss autophagic imbalance in RA and the regulatory mechanisms of circRNAs. We also explore possible targets for circRNA regulation of autophagy in RA, which may provide us with improved knowledge regarding the pathogenesis of RA.
Keyphrases
- rheumatoid arthritis
- cell death
- disease activity
- ankylosing spondylitis
- inflammatory response
- oxidative stress
- endoplasmic reticulum stress
- interstitial lung disease
- signaling pathway
- systemic lupus erythematosus
- stem cells
- healthcare
- small molecule
- lipopolysaccharide induced
- bone mineral density
- systemic sclerosis
- risk assessment
- immune response
- postmenopausal women
- climate change
- idiopathic pulmonary fibrosis
- lps induced
- body composition