Predicting Neoadjuvant Chemoradiotherapy Response in Locally Advanced Rectal Cancer Using Tumor-Infiltrating Lymphocytes Density.
Yao XuXiaoying LouYanting LiangShenyan ZhangShangqing YangQicong ChenZeyan XuMinning ZhaoZhen-Hui LiKe ZhaoZaiyi LiuPublished in: Journal of inflammation research (2021)
Patients with a high-TIL density have a higher major-responder rate than the low-TILs group, indicating patients with a strong immune response benefit more from nCRT. This semi-automatic method can facilitate the individualized preoperative prediction of the TRG for LARC patients before nCRT.
Keyphrases
- rectal cancer
- locally advanced
- neoadjuvant chemotherapy
- squamous cell carcinoma
- immune response
- phase ii study
- radiation therapy
- end stage renal disease
- newly diagnosed
- ejection fraction
- patients undergoing
- peripheral blood
- lymph node
- patient reported outcomes
- dendritic cells
- machine learning
- toll like receptor
- patient reported
- clinical trial
- open label