Poly (ADP-ribose) polymerases 16 triggers pathological cardiac hypertrophy via activating IRE1α-sXBP1-GATA4 pathway.

Haibi SuJie XuZhenghua SuChenxi XiaoJinghuan WangWen ZhongChen MengDi YangYizhun Zhu

Published in: Cellular and molecular life sciences : CMLS (2023)

Collectively, our results implicated that PARP16 is a contributor to pathological cardiac hypertrophy at least in part via activating the IRE1α-sXBP1-GATA4 pathway, and may be regarded as a new potential target for exploring effective therapeutic interventions of pathological cardiac hypertrophy and heart failure.

Keyphrases

heart failure
endoplasmic reticulum stress
transcription factor
signaling pathway
physical activity
left ventricular
atrial fibrillation
dna repair
climate change