Hydrogen Sulfide Modulates Endothelial-Mesenchymal Transition in Heart Failure.
Zhen LiHuijing XiaThomas E SharpKyle B LaPennaAntonia KatsoudaJohn W ElrodJosef PfeilschifterKarl-Friedrich BeckShi XuMing XianTraci T GoodchildAndreas PapapetropoulosDavid J LeferPublished in: Circulation research (2022)
Our data demonstrate that endothelial CSE modulates endothelial-mesenchymal transition and ameliorate the severity of pressure-overload-induced heart failure, in part, through nitric oxide-related mechanisms. These data further suggest that endothelium-derived hydrogen sulfide is a potential therapeutic for the treatment of heart failure with reduced ejection fraction.
Keyphrases
- heart failure
- nitric oxide
- endothelial cells
- left ventricular
- bone marrow
- stem cells
- electronic health record
- acute heart failure
- atrial fibrillation
- big data
- cardiac resynchronization therapy
- nitric oxide synthase
- hydrogen peroxide
- drug induced
- diabetic rats
- oxidative stress
- combination therapy
- data analysis
- smoking cessation