Anti-CD20 mAb-Induced B Cell Apoptosis Generates T Cell Regulation of Experimental Myeloperoxidase ANCA-Associated Vasculitis.
Poh-Yi GanJonathan DickKim-Maree O'SullivanVirginie OudinAnne Cao LeDaniel Koo Yuk CheongRaymond ShimMaliha AlikhanArthur Richard KitchingJoshua D OoiStephen R HoldsworthPublished in: Journal of the American Society of Nephrology : JASN (2021)
Collectively, these data suggest that, as well as reducing humoral autoimmunity, anti-CD20 mAb more rapidly induces protective anti-MPO Treg-mediated immunomodulation by splenic processing of anti-CD20-induced apoptotic B cells.