Pathogenic relevance of antibodies against desmoglein 3 in patients with oral lichen planus.

Dario DidonaMorna F SchmidtKatharina MeierAlberto Mesas-FernandezRoberto MaglieEmiliano AntigaMarisa KlempAmir S YazdiKamran GhoreschiMichael HertlChristian MöbsFarzan Solimani

Published in: Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG (2024)

Activation of humoral immunity occurs prevalently in patients with erosive OLP, probably due to epitope spreading. OLP serum antibodies are unable to induce loss of intercellular adhesion in vitro, strongly suggesting that they are not disease causing but rather an epiphenomenon.

Keyphrases

immune response
biofilm formation
monoclonal antibody
pseudomonas aeruginosa
staphylococcus aureus
escherichia coli