Nivolumab With or Without Ipilimumab in Pediatric Patients With High-Grade CNS Malignancies: Safety, Efficacy, Biomarker, and Pharmacokinetics: CheckMate 908.

Ira J DunkelFrançois DozNicholas K ForemanDarren HargraveAlvaro LassalettaNicolas AndréJordan R HansfordTim HassallMatthias EyrichSridharan GururanganUte BartelsAmar GajjarLisa HowellDeepti WaradMisena PaciusRachel TamYu WangLi ZhuKenneth Cohen

Published in: Neuro-oncology (2023)

NIVO±IPI did not demonstrate clinical benefit relative to historical data. The overall safety profiles were manageable with no new safety signals.

Keyphrases

high grade
blood brain barrier
electronic health record
big data
machine learning
young adults
deep learning