Analytical Sensitivity and Specificity of Four Point of Care Rapid Antigen Diagnostic Tests for SARS-CoV-2 Using Real-Time Quantitative PCR, Quantitative Droplet Digital PCR, and a Mass Spectrometric Antigen Assay as Comparator Methods.

Brad S KaronLeslie J DonatoAmber R BridgemanJoseph H BlommelBenjamin KippAnthony MausSantosh RenuseJennifer KempAkhilesh PandeyPatrick M VanderboomSandip ChavanSurendra DasariRavinder J SinghStefan K GrebeAkhilesh Pandey

Published in: Clinical chemistry (2021)

Ag RDTs differ significantly in analytical sensitivity, particularly at viral load <500 000 copies/mL.

Keyphrases

coronavirus disease
sars cov
high throughput
high resolution
liquid chromatography
real time pcr
single cell
highly efficient
loop mediated isothermal amplification
structural basis
visible light