Dissolution Profiles of Poorly Soluble Drug Salts in Bicarbonate Buffer.
Aoi SakamotoKiyohiko SuganoPublished in: Pharmaceutical research (2023)
The dissolution profiles of PIO HCl and DNT Na in BCB were markedly different from those in PB. Free-form precipitation on the particle surface, rather than in the bulk phase, was affected by buffer species in the dissolution test.