Differential expansion of T peripheral helper cells in early rheumatoid arthritis and osteoarthritis synovium.

William Murray-BrownYanxia GuoAnnabelle G SmallKatie LoweHelen WeedonMalcolm D SmithSusan E LesterSusanna M ProudmanNavin L RaoLing-Yang HaoSunil NagpalMihir D Wechalekar

Published in: RMD open (2022)

These data demonstrate that PD-1<sup>hi</sup> Tph cells are present in early rheumatoid arthritis, but not osteoarthritis synovium, and therefore may provide a target for treatment of patients with early rheumatoid arthritis.

Keyphrases

rheumatoid arthritis
induced apoptosis
disease activity
cell cycle arrest
interstitial lung disease
dendritic cells
signaling pathway
knee osteoarthritis
pi k akt
cell proliferation
replacement therapy