Effect of chronic unpredictable stress on the progression of experimental apical periodontitis in rats.
G B MinhotoRayana Duarte KhouryEsteban Isai Flores OrozcoRenata Falchete do PradoMarcia Carneiro ValeraPublished in: International endodontic journal (2021)
The chronic unpredictable stress model applied for 6 weeks exacerbated the inflammatory response and increased bone loss associated with AP, especially 21 days after its induction. This model appears to be suitable for investigating the bidirectional relationship between apical periodontitis and chronic stress.