Deletion of Mucosa-Associated Lymphoid Tissue Lymphoma Translocation Protein 1 in Mouse T Cells Protects Against Development of Autoimmune Arthritis but Leads to Spontaneous Osteoporosis.
Elisabeth GilisDjoere GaublommeJens StaalKoen VenkenMaarten DhaenensStijn LambrechtJulie CoudenysTine DecruyNadia SchryversYasmine DriegeEmilie DumasAnnelies DemeyerAmélie De MuynckJolanda van HengelLuc Van HoorebekeDieter DeforceRudi BeyaertDirk ElewautPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2019)
Overall, these data in murine models of RA highlight MALT-1 as a master regulator of T cell activation, which is relevant to the pathogenesis of autoimmune arthritis. Furthermore, these findings show that MALT-1 deficiency can lead to spontaneous osteoporosis, which is associated with impaired Treg cell numbers.
Keyphrases
- rheumatoid arthritis
- postmenopausal women
- bone mineral density
- multiple sclerosis
- disease activity
- single cell
- cell therapy
- electronic health record
- diffuse large b cell lymphoma
- drug induced
- transcription factor
- protein protein
- ankylosing spondylitis
- amino acid
- body composition
- interstitial lung disease
- systemic lupus erythematosus
- machine learning
- replacement therapy
- idiopathic pulmonary fibrosis
- data analysis