Overcoming platinum resistance in ovarian cancer by targeting pregnancy-associated plasma protein-A.

Diogo TorresXiaonan HouLaurie BaleEthan P HeinzenMatthew J MaurerValentina ZanfagninAnn L ObergCheryl ConoverJohn S Weroha

Published in: PloS one (2019)

The addition of mAb-PA to CP overcame platinum-resistance in one of five High PAPP-A PDX models; three other models demonstrated improved platinum-response. This supports further clinical development of this novel therapeutic.

Keyphrases

preterm birth
protein protein