Failures, Reoperations, and Improvement in Knee Symptoms Following Matrix-Assisted Autologous Chondrocyte Transplantation: A Meta-Analysis of Prospective Comparative Trials.
Joshua S EverhartEric X JiangSarah G PolandAmy DuDavid C FlaniganPublished in: Cartilage (2019)
Compared to microfracture, MACT has no increased risk of clinical failure and superior improvement in patient-reported outcome scores. Compared to MACT with standardized postoperative weight-bearing protocols, accelerated weight-bearing protocols have no increased risk of clinical failure and show superior improvement in patient-reported outcome scores. There is limited evidence regarding MACT compared to first-generation autologous chondrocyte implantation, mosaicplasty, and mesenchymal stem cell therapy without compelling differences in outcomes.
Keyphrases
- cell therapy
- patient reported outcomes
- stem cells
- mesenchymal stem cells
- bone marrow
- body mass index
- physical activity
- weight loss
- weight gain
- total knee arthroplasty
- patients undergoing
- type diabetes
- knee osteoarthritis
- adipose tissue
- platelet rich plasma
- depressive symptoms
- insulin resistance
- glycemic control
- anterior cruciate ligament