Methyltransferase like 7B is a potential therapeutic target for reversing EGFR-TKIs resistance in lung adenocarcinoma.
Huibin SongDongcheng LiuLingwei WangKaisheng LiuChen ChenLe WangYi RenBing JuFuhua ZhongXingyu JiangGuangsuo WangZhe-Sheng ChenChang ZouPublished in: Molecular cancer (2022)
This study uncovered a new critical link in METTL7B, glutathione metabolism and drug resistance. Our findings demonstrated that METTL7B inhibitors could be used for reversing TKIs resistance in LUAD patients.