Methyltransferase like 7B is a potential therapeutic target for reversing EGFR-TKIs resistance in lung adenocarcinoma.

Huibin SongDongcheng LiuLingwei WangKaisheng LiuChen ChenLe WangYi RenBing JuFuhua ZhongXingyu JiangGuangsuo WangZhe-Sheng ChenChang Zou

Published in: Molecular cancer (2022)

This study uncovered a new critical link in METTL7B, glutathione metabolism and drug resistance. Our findings demonstrated that METTL7B inhibitors could be used for reversing TKIs resistance in LUAD patients.

Keyphrases

end stage renal disease
small cell lung cancer
newly diagnosed
prognostic factors
epidermal growth factor receptor
tyrosine kinase
patient reported outcomes
human health