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Methyltransferase like 7B is a potential therapeutic target for reversing EGFR-TKIs resistance in lung adenocarcinoma.

Huibin SongDongcheng LiuLingwei WangKaisheng LiuChen ChenLe WangYi RenBing JuFuhua ZhongXingyu JiangGuangsuo WangZhe-Sheng ChenChang Zou
Published in: Molecular cancer (2022)
This study uncovered a new critical link in METTL7B, glutathione metabolism and drug resistance. Our findings demonstrated that METTL7B inhibitors could be used for reversing TKIs resistance in LUAD patients.
Keyphrases
  • end stage renal disease
  • small cell lung cancer
  • newly diagnosed
  • prognostic factors
  • epidermal growth factor receptor
  • tyrosine kinase
  • patient reported outcomes
  • human health