Synthesis and biological evaluation of RGD conjugated with Ketoprofen/Naproxen and radiolabeled with [99mTc] via N4(GGAG) for αVβ3 integrin-targeted drug delivery.

Reza MohammadiBahareh ShokriDanial ShamshirianAfshin ZarghiSoraya Shahhosseini

Published in: Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences (2019)

Provided that NSAID drugs are conjugated to RGD, there will be a selective delivery to target tissues as well as synergetic anti-tumor effects which reduce systemic doses and toxicity. Graphical abstract.

Keyphrases

drug delivery
cancer therapy
photodynamic therapy
gene expression
oxidative stress
drug induced
drug release
cell adhesion