Benefits of Budesonide/Glycopyrronium/Formoterol Fumarate Dihydrate on COPD Exacerbations, Lung Function, Symptoms, and Quality of Life Across Blood Eosinophil Ranges: A Post-Hoc Analysis of Data from ETHOS.
Mona BafadhelKlaus F RabeFernando J MartinezDave SinghPatrick DarkenMartin JenkinsMagnus AurivilliusMehul S PatelPaul DorinskyPublished in: International journal of chronic obstructive pulmonary disease (2022)
Benefits of BGF versus GFF were observed across EOS counts, particularly at ≥100 cells/mm³; versus BFF, benefits were largely independent of EOS. These findings confirm that benefits of ICS-containing triple therapy are not restricted to EOS counts ≥300 cells/mm³, supporting recommendations to consider triple therapy in patients with an exacerbation history and EOS counts ≥100 cells/mm³.
Keyphrases
- chronic obstructive pulmonary disease
- lung function
- induced apoptosis
- cell cycle arrest
- cystic fibrosis
- peripheral blood
- endoplasmic reticulum stress
- stem cells
- air pollution
- machine learning
- cell death
- cell proliferation
- bone marrow
- big data
- pi k akt
- cell therapy
- artificial intelligence
- data analysis
- mechanical ventilation