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A Toxoplasma gondii putative arginine transporter localizes to the plant-like vacuolar compartment and controls parasite extracellular survival and stage differentiation.

Federica PiroSilvia MasciGeetha KannanRiccardo FocaiaTracey L SchultzVernon B CarruthersManlio Di Cristina
Published in: bioRxiv : the preprint server for biology (2023)
manages its metabolism to adapt to changing environments and triggers its transformation into bradyzoites have hindered the discovery of vulnerabilities in its metabolic pathways or nutrient acquisition mechanisms to identify new therapeutic targets. In this work, we have shown that the lysosome-like organelle PLVAC, acting through the putative arginine transporter TgAAT1, plays a pivotal role in regulating the parasite's extracellular survival and differentiation into bradyzoites.
Keyphrases
  • toxoplasma gondii
  • nitric oxide
  • free survival
  • small molecule
  • high throughput
  • amino acid
  • plasmodium falciparum
  • fluorescent probe
  • life cycle