Rare gene fusion rearrangement SPTNB1-PDGFRB in an atypical myeloproliferative neoplasm.

Vanessa Fiorini FurtadoNeeraj Y SainiWilliam WalshVenu BathiniPatricia M Miron

Published in: Molecular cytogenetics (2018)

The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia recognizes a distinct class of myeloid and lymphoid tumors with eosinophilia-related proliferations associated with specific gene rearrangements, one of which involves rearrangements of platelet-derived growth factor receptor B (PDGFRB) gene. We report a case of a rare PDGFRB rearrangement with SPTNB1 (spectrin beta, nonerythrocytic 1) that presented as atypical myeloproliferative neoplasm.

Keyphrases

growth factor
copy number
genome wide
dendritic cells
genome wide identification
bone marrow
acute myeloid leukemia
low grade
total knee arthroplasty
immune response
gene expression
genome wide analysis
total hip arthroplasty