β-aminoisobutyric acid attenuates LPS-induced inflammation and insulin resistance in adipocytes through AMPK-mediated pathway.

Tae Woo JungHyung Sub ParkGeum Hee ChoiDaehwan KimTaeseung Lee

Published in: Journal of biomedical science (2018)

We demonstrated anti-inflammatory and anti-insulin resistance effects of BAIBA in differentiated 3 T3-L1 cells treated with LPS through AMPK-dependent signaling. These results provide evidence for the beneficial effects of BAIBA not only in liver and skeletal muscle cells but also in adipose tissue.

Keyphrases

skeletal muscle
insulin resistance
adipose tissue
lps induced
induced apoptosis
inflammatory response
anti inflammatory
cell cycle arrest
oxidative stress
high fat diet
metabolic syndrome
high fat diet induced
cell death
endoplasmic reticulum stress
signaling pathway
polycystic ovary syndrome
cell proliferation