HLA-DRB1 and DQB1 alleles in Japanese type 1 autoimmune hepatitis: The predisposing role of the DR4/DR8 heterozygous genotype.
Shomi OkaHiroshi FurukawaMichio YasunamiAya KawasakiHitomi NakamuraMinoru NakamuraAtsumasa KomoriSeigo AbiruShinya NagaokaSatoru HashimotoAtsushi NaganumaNoriaki NaeshiroKaname YoshizawaHaruhiro YamashitaKeisuke ArioHajime OhtaHironori SakaiIwao YabuuchiAtsushi TakahashiKazumichi AbeHiroshi YatsuhashiShigeto TohmaHiromasa OhiraNaoyuki TsuchiyaKiyoshi MigitaPublished in: PloS one (2017)
The important roles of specific combinations of DRB1 and DQB1 alleles or haplotypes in the pathogenesis of type 1 AIH were suggested. The association of DR4/DR8 heterozygous genotype suggested the pathologic importance of trans-complementing DQα-β heterodimer molecules encoded by DQA1 allele of one haplotype and the DQB1 allele of the other haplotype, as it was proposed in the HLA association studies of Type 1 diabetes.