Xenotransplantation of canine spermatogonial stem cells (cSSCs) regulated by FSH promotes spermatogenesis in infertile mice.

Naira Caroline Godoy PieriAna Carolina Furlanetto MançanaresAline Fernanda de SouzaHugo FernandesAngela Maria Gonella DiazaFabiana Fernandes BressanKelly Cristine Santos RoballoJuliana Barbosa CasalsMario BinelliCarlos Eduardo AmbrósioDaniele Dos Santos Martins

Published in: Stem cell research & therapy (2019)

In conclusion, our results showed for the first time that the treatment of cSSC cultures with FSH can promote in vitro self-renewal, increase the population of germline cells, and possibly influence the success of spermatogenesis in infertile mice in vivo.

Keyphrases

stem cells
high fat diet induced
induced apoptosis
polycystic ovary syndrome
cell cycle arrest
dna repair
type diabetes
insulin resistance
wild type
oxidative stress
mesenchymal stem cells
bone marrow
replacement therapy
skeletal muscle
smoking cessation
pi k akt