Advancing composite outcome measures: Insights on weighting components from OMERACT 2023.
George A WellsFrancis GuilleminPeter A MerkelMaarten de WitSarah MackieLyn MarchGunnar TómassonLauren K KingSam Michel CembaloShawna GrossklegLara J MaxwellSara MontiKaitlin A QuinnBeverley J SheaPeter TugwellDorcas BeatonPublished in: Seminars in arthritis and rheumatism (2024)
The OMERACT 2023 workshop underscored the significance of a systematic approach to weighting components in composite outcome development. It highlighted the complexity of achieving consensus on the importance of domains and the role of incorporating the perspectives of patient research partners in this process. Future research directions include refining weighting methodologies, moving composites through the OMERACT Filter and enhancing understanding of their implications for clinical trials. The findings contribute to the ongoing discourse on optimizing composite outcome measures in rheumatology and beyond, advocating for a balanced integration of scientific rigour and patient-centeredness in their development.