A p53/TIAF1/WWOX triad exerts cancer suppression but may cause brain protein aggregation due to p53/WWOX functional antagonism.
Pei-Yi ChouSing-Ru LinMing-Hui LeeLori SchultzChun-I SzeNan-Shan ChangPublished in: Cell communication and signaling : CCS (2019)
The WWOX/TIAF1/p53 triad is potent in cancer suppression by blocking cancer cell migration, anchorage-independent growth and SMAD promoter activation, and causing apoptosis. Yet, p53 may functionally antagonize with WWOX. p53 blocks WWOX inhibition of inflammatory immune response induced by cancer, and this leads to protein aggregation in the brain as seen in the Alzheimer's disease and other neurodegeneration.
Keyphrases
- papillary thyroid
- squamous cell
- immune response
- cell migration
- oxidative stress
- gene expression
- squamous cell carcinoma
- lymph node metastasis
- childhood cancer
- cell death
- dna methylation
- white matter
- epithelial mesenchymal transition
- transcription factor
- resting state
- blood brain barrier
- multiple sclerosis
- cell proliferation
- functional connectivity
- young adults
- cerebral ischemia
- small molecule
- amino acid
- toll like receptor
- mild cognitive impairment
- pi k akt