A novel PAX5 rearrangement in TCF3-PBX1 acute lymphoblastic leukemia: a case report.
Thayana Conceição BarbosaBruno Almeida LopesCaroline Barbieri BlunckMarcela Braga MansurAdriana Vanessa Santini DeylMariana EmerencianoMaria S Pombo-de-OliveiraPublished in: BMC medical genomics (2018)
To our knowledge, this is the first report of a rearrangement between PAX5 and SPECC1. The presence of TCF3-PBX1 and PAX5-rearrangement at diagnosis and relapse indicates that both might have participated in the malignant transformation disease maintenance and dismal outcome.