Dissection of transcriptomic and epigenetic heterogeneity of grade 4 gliomas: implications for prognosis.

Chang ZengXiao SongSheng ZhangQinyun CaiJiajun CaiCraig HorbinskiBo HuShi-Yuan ChengWei Zhang

Published in: Acta neuropathologica communications (2023)

The 5hmC-based prognostic model could offer a robust tool to predict survival in patients with grade 4 gliomas, potentially outperforming existing prognostic factors such as IDH1 mutations. The crosstalk between 5hmC and gene expression revealed another layer of complexity underlying the molecular heterogeneity in grade 4 gliomas, offering opportunities for identifying novel therapeutic targets.

Keyphrases

prognostic factors
single cell
high grade
gene expression
low grade
dna methylation
rna seq