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Delta opioid receptors on nociceptive sensory neurons mediate peripheral endogenous analgesia in colitis.

Xavier Mas-OreaLilian BassoCatherine BlanpiedClaire Gaveriaux-RuffNicolas CenacGilles Dietrich
Published in: Journal of neuroinflammation (2022)
The key role of DOR on primary afferents in relieving intestinal inflammatory pain opens new therapeutic opportunities for peripherally restricted DOR analgesics to avoid most of the side effects associated with MOR-targeting drugs used in intestinal disorders.
Keyphrases
  • pain management
  • chronic pain
  • neuropathic pain
  • postoperative pain
  • spinal cord
  • oxidative stress
  • cancer therapy
  • spinal cord injury
  • ulcerative colitis
  • chemotherapy induced