The artificial amino acid change in the sialic acid-binding domain of the hemagglutinin neuraminidase of newcastle disease virus increases its specificity to HCT 116 colorectal cancer cells and tumor suppression effect.
Bo-Kyoung JungYong Hee AnSung Hoon JangJin-Ju JangSeonhee KimJoo Hee JeonJinju KimJason Jungsik SongHyun JangPublished in: Virology journal (2024)
These results provide a new methodology for the use of directed evolution technology for more effective oncolytic virus development.