Prognostic Significance of Integrin Subunit Alpha 2 (ITGA2) and Role of Mechanical Cues in Resistance to Gemcitabine in Pancreatic Ductal Adenocarcinoma (PDAC).

Alessandro GregoriCecilia BergonziniMjriam CapulaGiulia Mantini Fatemeh Khojasteh-Leylakoohi Annalisa ComandatoreGhazaleh Khalili-TanhaAlireza KhooeiLuca Morelli Soodabeh Shahidsales Erik H J Danen Thomas Schmidt Elisa Giovannetti

Published in: Cancers (2023)

ITGA2 emerged as a new prognostic factor, highlighting the relevance of stroma mechanical properties as potential therapeutic targets to counteract gemcitabine resistance in PDAC.

Keyphrases

prognostic factors
locally advanced
squamous cell carcinoma
radiation therapy
risk assessment
climate change
cell migration