Severe pulmonary hypertension in aging female apolipoprotein E-deficient mice is rescued by estrogen replacement therapy.

Soban UmarRod Partow-NavidGregoire RuffenachAndrea IorgaShayan MoazeniMansoureh Eghbali

Published in: Biology of sex differences (2017)

Our results suggest that only aging female ApoE-deficient but not WT mice develop severe PH compared to younger females. Exogenous estrogen therapy rescued PH and RV hypertrophy in aging female ApoE-deficient mice possibly through restoration of lung ERβ.

Keyphrases

replacement therapy
pulmonary hypertension
estrogen receptor
cognitive decline
high fat diet
early onset
smoking cessation
pulmonary artery
pulmonary arterial hypertension
stem cells
breast cancer cells
drug induced
insulin resistance
wild type
mild cognitive impairment