Combined inhibition of CXCL12 and PD-1 in MSS colorectal and pancreatic cancer: modulation of the microenvironment and clinical effects.

Meggy Suarez-CarmonaAnja WilliamsJutta SchreiberNicolas HohmannUlrike PrueferJürgen KraussDirk JägerAnna FrömmingDiana BeyerDirk EulbergJarf Ulf JungeliusMatthias BaumannAram MangasarianNiels Halama

Published in: Journal for immunotherapy of cancer (2022)

We demonstrate that the combination of CXCL12 inhibition and checkpoint inhibition is safe and grants further exploration of synergistic combinatorial strategies.

Keyphrases

stem cells
dna damage
cell cycle
oxidative stress
cell proliferation
drug delivery