The Impact of Methenamine Hippurate Treatment on Urothelial Integrity and Bladder Inflammation in Aged Female Mice and Women With Urinary Tract Infections.
Jessica L SawhillAmy MoraKendall McDanielMarianne M LigonJerry L LowderIndira U MysorekarChristine M ChuPublished in: Female pelvic medicine & reconstructive surgery (2022)
Methenamine hippurate seems to enhance barrier function as evidenced by decreased urothelial permeability and increased urinary IgA levels, without worsening inflammation. This may reflect another beneficial mechanism by which MH helps prevent rUTI.