The functional ALDH2 polymorphism is associated with breast cancer risk: A pooled analysis from the Breast Cancer Association Consortium.
Tomotaka UgaiRoger L MilneHidemi ItoKristan J AronsonManjeet K BollaTsun ChanChing W ChanJi-Yeob ChoiDon M ConroyJoe DennisAlison M DunningDouglas F EastonValerie GaborieauAnna Gonzalez-NeiraMikael HartmanCatherine S HealeyMotoki IwasakiEsther M JohnDaehee KangSung-Won KimAva KwongArtitaya LophatananonKyriaki MichailidouNur Aishah Mohd TaibKenneth MuirSue K ParkPaul D P PharoahSuleeporn SangrajrangChen-Yang ShenXiao-Ou ShuJohn J SpinelliSoo H TeoDaniel C TessierChiu-Chen TsengShoichiro TsuganeDaniel VincentQin WangAnna H WuPei-Ei WuWei ZhengKeitaro MatsuoPublished in: Molecular genetics & genomic medicine (2019)
This study suggests that the Lys/Lys genotype confers susceptibility to BC risk among women of Asian ancestry, particularly for ER-positive, PR-positive, and HER2-negative tumor types.