Dyslipidemia, inflammation, calcification, and adiposity in aortic stenosis: a genome-wide study.
Hao-Yu ChenChristian DinaAeron M SmallChristian M ShafferRebecca T LevinsonAnna HelgadóttirRomain CapouladeHans Markus MunterAndreas MartinssonBenjamin J CairnsLinea C TrudsøMary HoekstraHannah A BurrThomas W MarshScott M DamrauerLine DufresneSolena Le ScouarnecDavid Messika-ZeitounDilrini K RanatungaRachel A WhitmerAmélie BonnefondGarðar SveinbjornssonRagnar DaníelsenDavid O ArnarGudmundur ThorgeirssonUnnur ThorsteinsdottirDaníel F GudbjartssonHilma HólmJonas GhouseMorten Salling OlesenAlex H ChristensenSusan MikkelsenRikke Louise JacobsenJoseph DowsettOle Birger Vesterager PedersenChristian ErikstrupSisse R Ostrowskinull nullChristopher J O'DonnellMatthew J BudoffVilmundur GudnasonWendy S PostJerome I RotterMark LathropHenning BundgaardBengt JohanssonJohan LjungbergUlf NäslundThierry Le TourneauJ Gustav SmithQuinn S WellsStefan SöderbergKári StefánssonJean-Jacques SchottDaniel J RaderRobert ClarkeJames C EngertGeorge ThanassoulisPublished in: European heart journal (2023)
Dyslipidemia, inflammation, calcification, and adiposity play important roles in the etiology of AS, implicating novel treatments and prevention strategies.
Keyphrases
- aortic stenosis
- transcatheter aortic valve replacement
- oxidative stress
- genome wide
- ejection fraction
- aortic valve replacement
- insulin resistance
- aortic valve
- transcatheter aortic valve implantation
- chronic kidney disease
- left ventricular
- dna methylation
- weight gain
- heart failure
- gene expression
- coronary artery disease
- adipose tissue
- metabolic syndrome
- body mass index
- type diabetes
- copy number
- weight loss